Manchester United will assess the fitness of Edinson Cavani and Donnie van de Beek, who were both left out of the Europa League squad on Thursday with muscular injuries. Scott McTominay is a doubt after he was substituted at Real Sociedad, while Paul Pogba remains out.
Newcastle United defender Federico Fernandez is back in training and could feature against Wolves next weekend. Jeff Hendrick returns from suspension but Callum Wilson is still sidelined.
Newcastle have lost seven of their past nine Premier League matches.
They have lost all three league games without scoring in the absence of Callum Wilson.
The striker has scored 10 and assisted five of Newcastle’s 25 league goals.
The Magpies have sustained nine defeats in 11 away matches and failed to score in eight of those fixtures.
Manager Steve Bruce has taken just one point from 11 Premier League visits to Old Trafford, a 2-2 draw with Sunderland in October 2009.
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